AIM • To assess serum Total Antioxidant Capacity (TAC) and impact of supplements on oxidative stress (OS) during pregnancy. INTRODUCTION Ø As placenta matures, it changes from a hypoxic environment to an oxygen-rich environment. Ø This favours the production of reactive oxygen species (ROS) which increases free iron concentration ( Liochevand Friedovich 1997). Ø Nitric oxide is also locally produced by the placenta ( Dotsch et al. 2001), and together with other reactive nitrogen species it contributes to the potential OS in the presence of transitional metals. Ø Macrophages infiltrate the placenta resulting in the production of free radicals, including reactive chlorine species. Preeclampsia is a perinatal disorder related to the OS taking place in the placenta. placental ischaemia results in OS characterised by an increase in levels of superoxide and lipid peroxidation products and decrease in levels of antioxidant